1954. US Marshal Teddy Daniels (Leonardo DiCaprio) travels to an offshore asylum for the criminally insane with his new partner Chuck (Mark Ruffalo). Daniels is supposedly investigating the mysterious disappearance of a murderess from her cell. On the island, Daniels comes to believe senior psychologists Cawley (Ben Kingsley) and Naehring (Max von Sydow) are involved in unethical experiments and a conspiracy to cover up the fate of Laeddis.

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